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KMID : 0043320100330081199
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Archives of Pharmacal Research
2010 Volume.33 No. 8 p.1199 ~ p.1207
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Optimization of promethazine theoclate fast dissolving tablet using pore forming technology by 3-factor, 3-level response surface-full factorial design
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Sharma Shailesh
Sharma Neelam
Gupta Ghanshyam Das
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Abstract
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The present research work was undertaken to optimize and formulate Promethazine Theoclate as a fast dissolving tablet using pore forming technology that disintegrates or dissolves rapidly and offer a suitable approach for the treatment of nausea and vomiting. Fast dissolving tablets of Promethazine Theoclate was prepared by increasing the solubility i.e. using β-cyclodextrin, crospovidone, and menthol. A 33 full factorial design was employed to investigate the combined influence of these three independent variables, i.e., amount of menthol, crospovidone and β-cyclodextrin on disintegration time, percentage friability and percentage drug release after 5 min. In the optimization study, multiple regression analysis has revealed that an optimum amount of menthol, crospovidone and β-cyclodextrin gives a rapidly disintegrating/dissolving tablet. In order to prove the validity of the evolved mathematical model a checkpoint batch was also prepared. Optimized tablets were prepared with an optimum amount of β-cyclodextrin, menthol and crospovidone which disintegrated in the 30 s, having friability 0.599% and released drug 89% after 5 min.
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KEYWORD
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Promethazine theoclate, Fast dissolving tablet, Optimization, Pore forming technology
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